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The Department of Chemistry – BMC conducts research and education in analytical chemistry, biochemistry and organic chemistry. More than 100 people, including around 45 PhD students, work at the department. New employees and students are recruited from all over the world and English is the main working language. The department is located at the Biomedical Centre in Uppsala, which facilitates collaborations with research groups in biology, pharmacy, medicine and SciLifeLab and gives access to advanced infrastructure for experimental and theoretical studies. The international environment and good opportunities for interdisciplinary collaborations enables PhD students at the department to participate in relevant research projects and prepare for an international research career.
Read more about the research at The Department of Chemistry – BMC at our website.
The position is one of eleven PhD positions in the Horizon Europe-funded Marie Skłodowska-Curie Action (MSCA) Doctoral Network IDPro, Intrinsically disordered proteins in health and disease: mechanisms, molecular context and opportunities for drug discovery.
IDPro is an exceptional network of nine beneficiaries (eight academic and one industrial) and five partner organizations (four industrial and three academic) from seven different countries, with excellent track records in protein research and supervision. Together, we will train eleven doctoral candidates, with distinct competencies of relevance for the field of intrinsically disordered proteins, to secure future scientific breakthroughs in a rapidly developing field. In particular, we will investigate how disordered proteins interact, how interaction is affected by disease-related mutations, and assess how disordered proteins cause aberrant cellular signaling in relevant human disease models. Furthermore, we will design ligands that can be further developed into molecular probes, which could represent lead structures for the development of drugs. The goal of IDPro is to strengthen an emerging field in biology and medicine with implications for both academia and industry in the European union.
In this project we will address fundamental questions related to how proteins such as kinases recognize binding sites in the intrinsically disordered regions of the proteome, and how these interactions are regulated and deregulated. The research will include heterologous expression and purification of proteins and identification and characterization of their interactions using a range of biophysical, biochemical and bioinformatics approaches.
Read more about our benefits and what it is like to work at Uppsala University
Duties
The main duties of PhD students are to devote themselves to their research studies, which includes participating in research projects and third cycle courses. The work duties can also include teaching and other departmental duties (not more than 20 % of full time).
Requirements
Great emphasis will be placed on personal qualities such as good collaborative skills, motivation and independence, as well as how the applicant through his/her experience and competence is judged to have the abilities necessary to develop within and acquire the doctoral education.
Additional qualifications
We are looking for a highly motivated person, with an ability to work independently and in collaboration with other groups. The candidate is expected to take initiative driving the project, but also to collaborate with the other members of the doctoral network.
The candidate should have a strong interest in pursuing a PhD degree in the field of protein science with a focus on intrinsically disordered proteins. The ideal candidate would be able to express and purify proteins in E. coli and perform basic characterization of the proteins.
Basic programming skills in Python and/or R are of added value.
Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines.
About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %. Starting date 11 November or as agreed. Placement: Uppsala
For further information about the position, please contact: Ylva Ivarsson, ylva.ivarsson@kemi.uu.se.
Please submit your application by 21 September 2023, UFV-PA 2023/2767.
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Type of employment | Temporary position |
---|---|
Contract type | Full time |
First day of employment | As agreed |
Salary | Fixed salary |
Number of positions | 1 |
Full-time equivalent | 100 % |
City | Uppsala |
County | Uppsala län |
Country | Sweden |
Reference number | UFV-PA 2023/2767 |
Union representative |
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Published | 20.Jul.2023 |
Last application date | 21.Sep.2023 11:59 PM CEST |