Uppsala University, Department of Pharmacy

The Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP) is located at the Department of Pharmacy, Uppsala University. The primary aim of UDOPP is to perform in vitro ADME (Absorption, Distribution, Metabolism and Excretion) investigations of hit collections and compound series during lead optimization in collaboration with academic research groups. The platform also performs preclinical characterization of lead and candidate drug compounds and bioanalytical services. The platform was formed in 2010 and is supported by a research group performing innovative research in the ADME and drug delivery field.

UDOPP is part of the Innovative Medicine Initiative (IMI) Conception consortium. UDOPP, the ENABLE2 platform, and as ADME of Therapeutics facility, the SciLifeLab Drug Discovery and Development platform (SciLifeLab DDD). For more information, please visit the following respective homepages at: Conception

The Swedish Government has authorized the Swedish Research Council (VR) to support the national research program ENABLE2. The aim of ENABLE2 is to establish a national drug discovery platform in Sweden for testing and optimizing molecules, which have the potential to become future drug candidates capable of treating resistant gram-negative infections (Enable). The ADMEoT (UDOPP) team is responsible for all in vitro ADME investigations within the ENABLE2 platform.

We are now recruiting a highly motivated and flexible in vitro ADME research assistant to expand our capacity. The position will be located at the ADMEoT facility (SciLifeLab DDD) at the department of Pharmacy at Uppsala University. Further information about the department and the research groups can be found at Farmaci

Duties: The candidate will perform daily experimental work with physicochemical, in vitro ADME and cell-based assays for small molecules and peptides. The successful candidate will analyze in vitro samples using the LC-MS/MS and report the results to the ENABLE2 project teams. The candidate will also work as an ADME project team member within the ENABLE2 platform.

Desired qualifications: The successful candidate should have a master's degree in biology, biochemistry, pharmacy or similar. The candidate should have 5 years of experience from the biotech/pharmaceutical industry and worked as a project member in preclinical drug development projects. Previous experience within infection and antibacterial drug development is an advantage.

The right applicant has good laboratory skills, including the ability to plan, design and perform experiments, analyze the data and report in vitro ADME results according to the regulatory agencies’ recommendations. Practical experience with the Caco2 and MDCK cells permeability assays and interpretation of the results is crucial.

Previous experience with outsourcing of the in vitro ADME assays and experience with analysis, especially with LC-MS/MS, are an advantage.

The right applicant should have good laboratory skills, including the ability to plan and conduct experiments, analyze data and report in vitro ADME results as recommended by regulatory authorities.

The ideal candidate is flexible, motivated, has good problem-solving ability and can deliver on short timelines. Good social skills, good co-operation skills and ability to present within interdisciplinary teams in English are required.

For further information about the position, please contact: Docent Pawel Baranczewski, pawel.baranczewski@farmaci.uu.se phone +46 (0) 707467894 or +46 (0) 18 4714967 (office).

Please submit your application by 6 December 2022, UFV-PA 2022/4304.

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Type of employment Temporary position
Contract type Full time
Number of positions 1
Full-time equivalent 100%
City Uppsala
County Uppsala län
Country Sweden
Reference number UFV-PA 2022/4304
Union representative
  • Seko Universitetsklubben, seko@uadm.uu.se
  • ST/TCO, tco@fackorg.uu.se
  • Saco-rådet, saco@uadm.uu.se
Published 20.Nov.2022
Last application date 06.Dec.2022 11:59 PM CET

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