Uppsala University, Department of Cell and Molecular Biology

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

The Department of Cell and Molecular Biology is organized into seven research programmes which all focus on different areas of cell and molecular biology: Computational Biology and Bioinformatics, Microbiology and Immunology, Molecular Biology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology and Structural Biology. The scientific basis of what we do lies in biology, but our research overlaps with other areas such as medicine, computer science, mathematics, chemistry, engineering sciences and physics. In total, we are over 200 staff and ~60 Ph.D. students. Please read more about the department’s work at https://icm.uu.se. The position is available in Jens Carlsson’s group in the computational biology and bioinformatics programme. Jens Carlsson’s research focuses on using molecular modeling to study protein-ligand interactions, in particular G protein-coupled receptors (GPCRs) and their interactions with drugs. The GPCR superfamily constitutes the largest group of human membrane proteins and plays key roles in physiological processes. The Carlsson group uses structure-based models to understand receptor function and to design ligands of these pharmaceutically important targets, often in close collaboration with experimental groups. The Carlsson group is an international research team and is also part of the Science for Life Laboratory (http://www.scilifelab.se/). Visit the group website for more information (www.carlssonlab.org).

Read more about our benefits and what it is like to work at Uppsala University

Duties
The project involves studies of how small molecules and peptides bind to GPCRs and enzymes using molecular modeling and machine learning. The methods that will be developed can be useful in drug discovery and the project also involves design of new molecules using structure-based virtual screening. The project focuses on receptors involved in neurological diseases and enzymes that are targets for antiviral drugs. The research will be carried out in close collaboration with experimental research groups.

Requirements
PhD degree in computational chemistry or a foreign degree equivalent to a PhD degree in the same area. Strong abilities in computational chemistry with experience in simulations of proteins are required. Excellent written and oral knowledge of English is required as the work takes place in an international environment. We attach great importance to personal qualities, in particular good collaborative abilities, motivation, and independence.

Additional qualifications
Experience in modelling of GPCRs, molecular docking, machine learning and scientific programming is preferred, but not required.

About the employment
The employment is a temporary position of 12 months. Scope of employment 100 %. Starting date as soon as possible or as agreed. Placement: Uppsala

For further information about the position, please contact:
Jens Carlsson, jens.carlsson@icm.uu.se, Tel: +46 (0)72 227 7976.

Please submit your application by November 25 2022, UFV-PA 2022/4195.

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Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment 2022-12-01
Salary Individual salary
Number of positions 1
Full-time equivalent 100%
City Uppsala
County Uppsala län
Country Sweden
Reference number UFV-PA 2022/4195
Union representative
  • Seko Universitetsklubben, seko@uadm.uu.se
  • ST/TCO, tco@fackorg.uu.se
  • Saco-rådet, saco@uadm.uu.se
Published 11.Nov.2022
Last application date 25.Nov.2022 11:59 PM CET

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