Uppsala University, Department of Pharmacy

The Department of Pharmacy offers a stimulating multidisciplinary working environment in research and teaching within the Pharmacy disciplines. The Department centers its research on Drug Delivery, Rational Drug Usage and Pharmaceutical Materials Science. The research is developed by a series of research groups, several of international prominence. The research groups represent a unique cluster of academic competences in Sweden and the Department of Pharmacy has thus a key role in the development of the pharmacy discipline in Sweden. Information about the department and the research groups can be found at www.farmfak.uu.se/farm/.

The post doc will be linked to the research group Drug Delivery and the Swedish Drug Delivery Forum. The group takes a multidisciplinary approach and combines computational chemistry and bioinformatics with cell- and molecular biology, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict and define rate-limiting barriers to the absorption and organ distribution of different types of drugs. We anticipate that our research will provide insights into new mechanisms for drug absorption, disposition and delivery, which will support development of new therapeutic strategies for efficient oral drug delivery.

Duties/Project description:

The post doc will work within the project Small scale and microfluidics tools for prediction of gastrointestinal drug absorption. The project targets development of new in vitro tools that will better describe drug transport in the small and large intestine as well as the diffusion across the mucosa. Focus is on generating more complete small scale tools that are capturing the dynamics in the intestine with regard to flow pattern and flow rate, pH and bile gradients and differences in physiology of the mucosa. The post doc will work in a team which develops new cell-based models and 3D-printed intestinal structures applicable in the screening of formulation performance. The developed tools are expected to facilitate the understanding of drug transport, drug dissolution and release, drug diffusion across mucus and drug transport across cell-layers, and hence, improve the assessment of formulation performance. Both traditional (small sized) drug molecules and macromolecular drugs will be investigated. Techniques to be used in the project are strongly related to biorelevant profiling and molecular pharmaceutics with material and particle characterization, dissolution and release studies, imaging of flow pattern and concentration determination with UPLC-UV-MS/MS.

Requirements:

To qualify for an employment as a postdoctor you must have a PhD degree or a foreign degree equivalent to a PhD degree in a subject that is relevant to the project.  Extra attention will be paid to scientific skills and e.g. PhD in Pharmaceutics, Biopharmaceutics, Chemical Engineering or other relevant area is highly rated. The PhD degree must have been obtained no more than three years prior to the application deadline. The three year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. The candidate must have good communication skills in oral and written English. Further the post doc is expected to successfully perform high quality research, publish the results, develop new methodologies and independently perform the tasks included in the project. He/she is also expected to actively contribute to other projects performed in the group and to the common goals of the team.

Additional qualifications:

Previous work with biorelevant dissolution profiling and/or different transfer systems of relevance for intestinal flow and motility is meritorious.

How to apply:

The application should contain a letter in which the applicant describes her- or himself, motivates why she/he has applied for the position, states relevant qualifications and indicates research interests and plans for the future. It must contain a CV including at least two references, authorized copies of relevant certificates, degrees and grades, and copies of your thesis and other documents, such as publications, that you want to invoke.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: Individual salary.
 
Starting date: 01-05-2019 or as otherwise agreed.

Type of employment: Temporary position according to central collective agreement.

Scope of employment: 100 %

For further information about the position please contact: Associate Professor Christel Bergström, tel 018-471 4118, e-post christel.bergstrom@farmaci.uu.se

Please submit your application by 18 April 2019, UFV-PA 2019/905.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Type of employment Temporary position
Contract type Full time
First day of employment 2019-05-01
Salary Fixed salary
Number of positions 1
Full-time equivalent 100 %
City Uppsala
County Uppsala län
Country Sweden
Reference number UFV-PA 2019/905
Union representative
  • Seko Universitetsklubben, seko@uadm.uu.se
  • ST/TCO, tco@fackorg.uu.se
  • Saco-rådet, saco@uadm.uu.se
Published 27.Mar.2019
Last application date 18.Apr.2019 11:59 PM CEST

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