PhD position in the research group of Experimental and Clinical Oncology - Hiring in process/Finished, not possible to apply

The Department of Immunology, Genetics and Pathology at Uppsala University (www.igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 400 million, out of which more than half is made up of external funding. The staff amounts to approximately 340 employees, out of which 100 are PhD-students, and there are in total more than 600 affiliated people.

Project description:
A PhD student position is available for highly motivated individual with interest in epigenetics within the group of Prof. Jernberg Wiklund at Uppsala University, Dept. of Immunology, Genetics and Pathology. The research group has a well-established record on the importance of Polycomb gene targeting for the plasma cell malignancy multiple myeloma (MM). The aim of this doctoral project is to uncover the Polycomb interactome in MM by investigating proteins and non-protein-coding RNAs interacting with the Polycomb repressor complex 2 (PRC2).The doctoral student will employ both well-established within the group techniques such as Chromatin immunoprecipitation (ChIP) and novel techniques such as protein and RNA co-immunoprecipitation (co-IP and RIP). Hypothesis driven single gene/protein level analyses as well as global investigatory analyses by next generation sequencing and mass spectrometry proteomics will be performed. These approaches will be followed by in-depth molecular studies on identified hits and further investigation of their targeting by small chemical inhibitors, both in vitro and in vivo, as potential novel therapeutic strategies in MM.

Further information on the activity of the research group can be accessed at http://www.igp.uu.se

The successful candidate will devote most of the time towards his/her research level education. Other service activities within the department, e.g. education and administrative work can be included within the framework of the employment (maximum 20%). The position will be extended with the time devoted to teaching to allow four years of full time graduate studies.

Qualifications:
The applicant should have MSc degree in molecular cell biology or a related field. We are looking for a dedicated and ambitious candidate with a solid experience in basic laboratory cell biology techniques such as handling cell cultures, western blotting, qPCR and basic statistics. A strong interest in epigenetics, bioinformatics and cancer biology is a must. In addition a working knowledge on bioinformatic analyses of ChIP- and RNA-seq would be highly valued. Very good oral and written communication skills in English are required. Emphasis will also be given on personal qualities such as collaboration and communication skills as well as analytical capacity. The candidate is expected to take initiatives as well as to collaborate with national and international colleagues both within and outside of the group.

The application should include a CV, copies of exams, degrees and grades, contact details of two references and a short description of the applicant and his/her experience. Letters(s) of recommendation may be included. If the applicant has published scientific papers, they can also be included. Information about education at the postgraduate level, admission requirements and admission decisions can be found at http://www2.medfarm.uu.se/utbildning/forskarniva/vill_du_borja/

Selection of applicants will be done by the future tutor for the selected student in consultation with the postgraduate study group of the Department. The Postgraduate Programs Committee at the Disciplinary Domain of Medicine will formally approve the student's admission.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: According to local agreement for PhD students and teaching assistants.

Starting date: As soon as possible or as otherwise agreed.

Type of position: Full time position.

For further information about the position please contact: Prof. Helena Jernberg Wiklund, helena.jernlund_wiklund@igp.uu.se

You are welcome to submit your application no later than 2018-12-07, UFV-PA 2018/4162

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.