Uppsala University, Department of Cell and Molecular Biology

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our mission is to pursue top-quality research and education and to interact constructively with society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Department of Cell and Molecular Biology is one of the most international, broad and distinguished bio-molecular departments in Europe, comprising six research programs with about 130 employees. This position is within the research lab of Sebastian Deindl (deindl‑lab.com).

Overall description
Molecular machines are proteins that convert chemical energy into conformational changes to carry out work in the cell. Our group studies the structural architectures and dynamics of molecular machines with focus on nucleic-acid interacting enzymes whose aberrant function or dysregulation is often associated with severe disease states. Single-molecule imaging approaches that directly visualize molecular machines in real time give us a unique possibility to decipher their complex regulation and correlate structural dynamics with function. 

Job assignment
We use an innovative approach to characterize the dynamics and regulation of chromatin-associated protein machines. As part of a project funded by an ERC starting grant, you will apply structural approaches with the ultimate goal to describe function and regulation of chromatin remodeling enzymes. This assignment comprises experimental design, data acquisition and state-of-the-art data analysis. You will carry out experiments independently but also interact with other members of the team.    

Qualifications required
The applicant must have a PhD in structural biology or an equivalent area that the employer assesses as equivalent. The applicant should have experience with with crystallization of DNA-bound protein complexes and their structure determination, heavy atom-screening and structure solution by SAD and have experience with expression and purification of proteins. Great emphasis will be placed on personal skills and characteristics, such as great interpersonal skills. The applicant must also have good communication skills in English, which is a prerequisite for the service, due to the international environment.

Qualifications desired

  • Experience with protein chemistry
  • Experience with molecular cloning
  • Proficient in standard biochemistry methods
  • Experience with spectroscopy

The application must include

  • A CV with your full publication list,
  • Copies of diplomas and certificates,
  • Contact details of two references,
  • A personal letter including a short description of your research interests.

The application will be evaluated based on the following criteria: Appropriate education and work/research in related fields and fulfillment of the listed qualifications.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Pay: Individual salary

Starting: 1st of January 2018 or according to agreement

Type of employment: Temporary position for two years.

Working hours: 100 %

For further information about the position please contact Sebastian Deindl (sebastian.deindl@icm.uu.se)

You are welcome to submit your application no later than no later than 15th of November 2018, UFV-PA 2018/3634

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.

Type of employment Temporary position longer than 6 months
Contract type Full time
First day of employment 190101
Salary Fixed salary
Number of positions 1
Working hours 100%
City Uppsala
County Uppsala län
Country Sweden
Reference number UFV-PA 2018/3634
Union representative
  • Ellena Papaioannou, Seko, 018-471 3315
  • Suzanne Borén Andersson, TCO/ST, 018-471 6251
  • Per Sundman, Saco-rådet, 018-471 1485
Published 25.Oct.2018
Last application date 15.Nov.2018 11:59 PM CET

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