One or up to two researchers in Chromatin Function and Regulation - Hiring in process/Finished, not possible to apply

One or up to two researchers in Chromatin Function and Regulation

The Department of Cell and Molecular Biology is one of the most international, interdisciplinary and successful biomolecular research centers in Europe. The department consists of six research programs with approximately 130 employees. The announced position is part of Sebastian Deindl's research group at the molecular system biology program (deindl lab.com).

Project
Molecular machines are proteins that convert chemical energy into conformational changes in order to perform work in the cell. Our group studies the structural architecture and dynamics of the molecular machines with focus on DNA-interacting enzymes. Malfunction or misregulation of these enzymes is often associated with severe diseases. By studying single molecules in real time we can visualize the molecular machines at work, giving us a unique opportunity to decipher the complex regulatory mechanisms and correlate the structural dynamics with the function of the protein complexes.

Work Description
The hired researcher(s) will study the function of various nucleic acid-interacting protein machines using a combination of biochemical methods in vitro. The project aims at investigating how these machines interact with their substrates (nucleic acids and nucleosomes) and how the catalytic activity is regulated. The long-term goals are to highlight the importance of sequence variations for the catalytic activity, regulation and function. The project involves experimental design as well as data collection and analysis. You will work on the purification of proteins and nucleic acids, as well as with the construction of genetic libraries.

Required qualifications
The applicant must have a doctorate in molecular biology, or other related, relevant area that the employer assesses as equivalent. The applicant should have experience with molecular biology techniques, construction of plasmid / transposon libraries, as well as the assembly and purification of nucleosomes using salt gradient dialysis.Great emphasis will be placed on personal skills and characteristics, such as great collaborative skills. The applicant must also have good communication skills in English, both in speech and in writing, This is a prerequisite for the service. due to the international environment.

Desired qualifications

• Experience of foot-print assays and/or blotting techniques to investigate protein-nucleic acid interactions
• Experience in the expression and purification of proteins using diverse chromatography techniques. 

The project is collaborative and in addition to scientific qualifications we value interpersonal skills.

The application should contain

• CV with publication list
• Degree certificates Contact
• information for two reference persons
• A cover letter describing your scientific interests

The application will be evaluated based on the following criteria: Appropriate education research experience in relevant areas.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Pay: Individual salary

Starting: 1st of January 2019 or according to agreement

Type of employment: Temporary position for two years.

Working hours: 100 %

For further information about the position please contact 
Stefan Knight (stefan.knight@icm.uu.se)

You are welcome to submit your application no later than no later than 15th of November 2018, UFV-PA 2018/3633.

 Are you considering moving to Sweden to work at Uppsala University? If so, you will find much information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact the International Faculty and Staff Services at ifss@uadm.uu.se.