Researcher in Biochemistry Directed evolution of CO2 reducing enzymes

The Department of Chemistry - Ångström conducts research and education in the chemistry field. The department has more than 270 employees and has a turnover of 300 million SEK. At the department's six programs, we conduct very successful research of a high international standard. We have a large number of externally funded research projects, often with international cooperation and we see continued good growth in our subject area. The department has education assignments in engineering programs and master's programs. More information is available on our website. 

Duties

Carbon monoxide dehydrogenase (CODH) enzymes are highly active catalysts with regards to the reversible reduction/oxidation of CO2. Consequently, they are intensively studied due to their biotechnological potential. The project follows one of the major project lines in the group, which focuses on ancestral reconstruction and directed evolution of CODHs with the aim of developing biocatalysts that can be applied in CO2 fixation.

The applicant will work in an interdisciplinary project that involves molecular biology, bioinformatics, biochemistry and biophysics. The primary role of the researcher will deal with directed evolution of CODH including library screening under anaerobic conditions. This with the aim of identifying mutations that increase CO2 reduction activity. Successful mutants will be characterized in depth utilizing a combination of electrochemistry, spectroscopy and structural biology, with a focus on determining the mechanism behind the improved properties. The project will be led by the researcher in collaboration with spectroscopists and structural biologists at Uppsala University, within Sweden, and abroad.

The main duty of the researcher is to devote themselves to their research but work duties may also include supervision of degree projects and doctoral students.

Requirements 

• PhD degree in biochemistry, molecular biology or similar, or a foreign degree equivalent to a PhD degree
• experience in directed evolution
• experience in biocatalysis, bioinformatics, biochemistry, biophysics and/or bioinorganic chemistry
• Written and oral English skills

We will place great emphasis on personal suitability. Consideration will also be given to i.e. good collaborative skills, drive and independence, and how the applicant’s experience and skills complement and strengthen the administrative work within the unit/department, as well as contribute to its future development.

About the employment

The employment is a temporary position, 2026-12-31. Scope of employment 100 %. Starting date 2026-02-01. Placement: Uppsala, Sweden

For further information about the position, please contact: Dr. Henrik Land, e-mail: henrik.land@kemi.uu.se

Please submit your application by 8th of Jan 2026, UFV-PA 2025/4039.