Research Assistant - Hiring in process/Finished, not possible to apply

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focusing on cancer, genetic and autoimmune diseases. A fundamental idea at the department is to stimulate translational research and thereby promote closer interactions between medical research and health care. Research is presently organized in six research programs: Cancer Precision Medicine, Cancer Immunotherapy, Genomics and Neurobiology, Molecular Tools and Functional Genomics, Neuro-Oncology and Neurodegeneration and Vascular Biology. Departmental activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Uppsala University Hospital. The department has teaching assignments in several education programs, including Master Programs, at the Faculty of Medicine. The department has a yearly turnover of around SEK 550 million, out of which about two thirds derive from external funding. IGP has approximately 400 employees, out of which 100 are PhD-students, and there are in total more than 850 affiliated staff members. More information about the department's activities can be found here: www.uu.se/en/staff/department/immunology-genetics-and-pathology

Workplace:
This position is a joint-post between Koltowska’s lab and DanioReadout. DanioReadout provides a full-offer, customized, genome engineering and substance exposure service integrated with phenotypic evaluation in the intact zebrafish embryo. Our three main service areas are the modelling of human genetic diseases, with experience in generating nearly 200 novel gene knock-out models, substance exposure studies and human cancer modelling. All service areas are integrated with a unique in-house developed automated image capture pipeline and data analysis using artificial intelligence. We are open to meeting facility users’ needs, by developing disease models and analysis methods specific for each project. Koltowska’s lab focuses on lymphatic vessel development. We utilise transgenic and mutant lines in conjunction with microscopy to study the molecular factors necessary for lymphatic vessel formation and function. 

Work description:  
This position will include standard molecular biology tasks, managing zebrafishfish breeding and maintaining appropriate records and zebrafish embryos. Work including phenotypical studies and work with microscopes will be part of the duties. Weekend work may be required.

Duties:
Establishment, application and improvement of the following methods: 
- Zebrafish handling with embryo injections 
- Basic coding skills for microscopy and analysis 
- Bioinformatic analysis / biological interpretation of sequencing results 
- Microscopy and analysis (high-through put, fluorescent brightfield, Fiji) 
- Zebrafish colony maintenance (including mutant lines). 
- Usage and management of specific transgenic zebrafish 
- Founders and stable line generations of zebrafish 
- Generation of transgenic lines, CRIPRS mutants  
- Molecular biology (cloning, gel electrophoresis) 
- Microinjection and microdissections (including lymphangiogram and angiogram). 
- Histological techniques (immunohistochemistry and in situ hybridisation) 
- Visualization of blood and lymphatic endothelial cells, vessels, and phenotypic analysis

Required Qualifications: 
Master's degree, or skills that the employer considers equivalent. 
We are looking for qualified and motivated candidates with an interest and experience in molecular biology and animal health and various microscopy methods. Previous experience of working with zebrafish is essential.
Good interpersonal skills as well as the ability to work both independently and in groups are required. 
An ability to initiative and a structured approach is important for this position. 
You will be expected to be efficient, accurate, and eager to develop new operations. Particular emphasis will be placed on personal suitability. The position requires excellent English language skills.

Desired Qualifications:
Master's degree in Life Science
Courses in Laboratory Animal Science, Fish and Swedish Legislation, Ethics and Animal Use and 3R or equivalent will be an advantage. 

The application should include a brief description of relevant experience, CV, copies of diplomas and certificates and other documents that the applicant wishes to submit for consideration. Include contact information for two references.  

About the employment
The employment is a permanent position, probationary period may be applied. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Beata Filipek-Gorniok; e-mail: beata.filipek.gorniok@uu.se, Kaska Koltowska; e-mail: kaska.koltowska@igp.uu.se

Please submit your application by 6 October 2025, UFV-PA 2025/2748

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