Researcher in Analytical Chemistry – Untargeted and Targeted Metabolomics

We are seeking a highly motivated researcher in analytical chemistry with expertise in global (untargeted) and targeted metabolomics to join the ADME of Therapeutics (ADMEoT) unit at the Department of Pharmacy, in collaboration with the Globisch Laboratory at the Department of Chemistry-BMC. Both departments are located at the Biomedical Centre (BMC), Uppsala University, Uppsala, Sweden.

Workplace
Uppsala University is a leading international research institution, with more than 53,000 students and 7,600 employees. We offer an inspiring academic environment with world-class infrastructure and a strong commitment to top-tier research, education, and societal engagement. Uppsala University is one of the four founding institutions of Science for Life Laboratory (SciLifeLab), a nationally recognized center for infrastructure and research in translational medicine and molecular biosciences.

As part of this initiative, the SciLifeLab Drug Discovery and Development Platform (SciLifeLab DDD) was created to support academic drug discovery in Sweden. Within this platform, the ADME of Therapeutics (ADMEoT) — also known as Uppsala University Drug Optimization and Pharmaceutical Profiling (UDOPP) — operates as a specialized unit in the Department of Pharmacy, Faculty of Pharmacy. The unit focuses on in vitro ADME (Absorption, Distribution, Metabolism, and Excretion), bioanalysis, and pharmacokinetic (PK) profiling during early drug discovery.
More information: UDOPP

The Department of Pharmacy at Uppsala University offers an interdisciplinary environment at the forefront of pharmaceutical sciences. With cutting-edge research, top-tier education, and extensive collaborations, we are a key force in the field. Our core competencies include in vitro ADME models, advanced in vivo methods, computational modeling and simulation, as well as patient-focused and policy-related studies, ranging from individual drug optimization to pharmaceutical policy analysis.
More about our research: Department of Pharmacy

The Department of Chemistry-BMC at Uppsala University conducts research and education in analytical chemistry, biochemistry, and organic chemistry. Comprising over 100 staff members, it fosters a vibrant international research environment. Located at BMC, the department benefits from close proximity to leading research groups in biology, pharmacy, medicine, and SciLifeLab, enabling extensive collaboration and access to cutting-edge infrastructure for experimental and theoretical work.
More information: Analytical Chemistry

Among the department's research groups, the Globisch Laboratory is a multidisciplinary team focused on exploring human metabolism and its interaction with the gut microbiome.

About the Role
You will support the Swedish academic drug discovery initiatives by providing expertise in sample preparation, metabolomics, including structure elucidation using mass spectrometry. Your role will include developing and implementing analytical workflows for both untargeted and targeted metabolomics of in vitro and in vivo biological samples. You will also contribute to method development and data analysis pipelines.

The position is based in the ADMEoT unit at the Department of Pharmacy (BMC), in collaboration with the Department of Chemistry and the Globisch Laboratory, Uppsala University.

Key Responsibilities

-Develop and optimize sample preparation protocols for metabolomics analysis of in vitro (e.g., cell cultures) and in vivo (e.g., plasma, urine, tissue) samples.

-Design and conduct untargeted and targeted LC-MS/MS assays to profile metabolic changes.

-Set up, operate, and maintain high-resolution mass spectrometers (MS), interpret and analyze experimental data.

-Develop and improve MS-based workflows for rapid identification of primary and secondary metabolites, including pathway analysis.

-Analyze and interpret data to guide experimental design and support project decisions.

-Evaluate and recommend strategies to optimize metabolomics resources for drug discovery projects.

-Build and implement informatics pipelines for metabolomics data analysis, comparison, and visualization.

-Integrate software tools for data processing, biomarker discovery, and predictive modeling.

-Serve as the metabolomics expert in interdisciplinary teams, including within the Department of Chemsitry-BMC, the Globisch Laboratory, and SciLifeLab DDD.

-Collaborate with researchers nationally and internationally.

Qualifications

A Ph.D. in Analytical Chemistry, Metabolomics, Mass Spectrometry, or a related field, with at least 2 years of relevant postdoctoral or industry experience. Proven hands-on experience in analytical chemistry and operation of liquid chromatography and (high-resolution) mass spectrometry systems, including: Handling and sample preparation of in vitro and in vivo biological samples Developing and implementing liquid chromatography methods Experience with Waters QToF and triple quadrupole instruments, and Waters Connect (Unifi) software Experience with Thermo Orbitrap instruments and Compound Discoverer software Competency in modern data acquisition and quantitative analysis methods Knowledge of regulatory requirements for bioanalytical method validation Experience with Gas Chromatography-Mass Spectrometry is an advantage Demonstrated expertise in both untargeted and targeted metabolomics workflows, including MS-based structure elucidation of secondary metabolites. Strong understanding of statistics and statistical modeling applied to metabolomics. Motivation to work hands-on in a laboratory setting with a collaborative, team-oriented mindset. Ability to develop, validate, and implement new laboratory techniques is advantageous. Excellent communication skills in English, both written and spoken. Strong data management, analysis, and interpretation skills. Demonstrated ability to work in interdisciplinary teams and integrate metabolomics with biological and pharmacological datasets. 

About the employment
The employment is a permanent position (probationary period may be applied). Scope of employment 100%. Starting date 1 October 2025 or as agreed. Placement: Uppsala

For further information about the position, please contact: Assoc. Prof. Pawel Baranczewski: pawel.baranczewski@uu.se tel: +46 707 467894
Prof. Daniel Globisch: daniel.globisch@kemi.uu.se tel: +46 18 471 3630

Please submit your application by 11 August 2025, UFV-PA 2025/2047.

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