Research Engineer

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focusing on cancer, genetic and autoimmune diseases. A fundamental idea at the department is to stimulate translational research and thereby promote closer interactions between medical research and health care. Research is presently organized in six research programs: Cancer Precision Medicine, Cancer Immunotherapy, Genomics and Neurobiology, Molecular Tools and Functional Genomics, Neuro-Oncology and Neurodegeneration and Vascular Biology. Departmental activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Uppsala University Hospital. The department has teaching assignments in several education programs, including Master Programs, at the Faculty of Medicine, and the Faculty of Science and Technology. The department has a yearly turnover of around SEK 550 million, out of which about two thirds derive from external funding. IGP has approximately 400 employees, out of which 100 are PhD-students, and there are in total more than 850 affiliated staff members. More information about the department's activities can be found here: www.uu.se/en/staff/department/immunology-genetics-and-pathology

Duties
The Fürth Lab at SciLifeLab/Uppsala University develops state-of-the-art molecular tools to investigate gene expression and RNA–protein interactions at the single-cell and subcellular level. We are looking for a talented and self-motivated research engineer to join our team and contribute to the development and application of innovative technologies at the interface of synthetic chemistry, advanced microscopy, and molecular biology. The lab is structured around two complementary tracks: one focused on designing novel chemical probes and bio-orthogonal labeling strategies, and the other on applying molecular biology techniques such as live-cell imaging, single-molecule RNA detection, and sequencing-based approaches. By combining these efforts with advanced optics and microscopy, the lab creates powerful new methods for mapping when, where, and how genes are regulated inside living cells. In parallel these tools are applied to address fundamental questions in neuroscience—particularly how information is stored, transmitted, and preserved at the cellular level in the nervous system despite the constant molecular turnover inherent to biological systems. With a strong emphasis on technology development and interdisciplinary collaboration, the lab is committed to pushing the boundaries of spatial and temporal transcriptomics. 
The successful candidate will play a key role in ongoing research projects within the lab, focusing on cell-based experiments, molecular techniques, and assay development. Responsibilities include:
- Maintaining and performing experiments in mammalian cell cultures.
- Applying advanced cell biology techniques to study cellular processes.
- Conducting molecular biology work, including sequencing, cloning, and gene expression analysis.
- Performing microscopy-based experiments, including live-cell imaging and single-molecule fluorescence in situ hybridization (smFISH).
- Assisting in the development and optimization of novel methodologies.
- Supporting collaborative research efforts and training lab members in relevant techniques.
- Close collaboration with management to plan research and teaching activities within the laboratory and ensure that projects are implemented and completed on time. 

Requirements
- Extensive experience in mammalian cell culture techniques.
- Strong expertise in molecular biology techniques,  including cloning, qPCR, and Western blotting.
- Extensive hands-on experience with advanced microscopy techniques, with a particular focus on high-throughput fluorescent imaging and live-cell applications
- Demonstrated ability to work independently and collaboratively in a research setting.

Additional qualifications
- PhD in Cell Biology, Molecular Biology, Biotechnology, or a related field.
- Prior experience in large-scale omics projects involving multiple stakeholders is highly valued.
- Hands-on experience with microscopy techniques involved in live-cell imaging and smFISH is meriting.

About the employment
The employment is a permanent position, probationary period may be applied. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Daniel Fürth, daniel.furth@igp.uu.se

Please submit your application by 28 April 2025, UFV-PA 2025/967.

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