Researcher

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focusing on cancer, genetic and autoimmune diseases. A fundamental idea at the department is to stimulate translational research and thereby promote closer interactions between medical research and health care. Research is presently organized in six research programs: Cancer Precision Medicine, Cancer Immunotherapy, Genomics and Neurobiology, Molecular Tools and Functional Genomics, Neuro-Oncology and Neurodegeneration and Vascular Biology. Departmental activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Uppsala University Hospital. The department has teaching assignments in several education programs, including Master Programs, at the Faculty of Medicine, and the Faculty of Science and Technology. The department has a yearly turnover of around SEK 550 million, out of which about two thirds derive from external funding. IGP has approximately 400 employees, out of which 100 are PhD-students, and there are in total more than 850 affiliated staff members. More information about the department's activities can be found here: www.uu.se/en/staff/department/immunology-genetics-and-pathology

Duties
The project is focused on vascular permeability and the implementation of a new form of treatment for excessive vascular permeability in eye disease. The tasks include the following:
- Injection of inhibitory substance into skin (so-called Miles assay) or eyes (intravitreal) of rodent models, followed by monitoring of leakage of circulating fluorescent substances into the tissue.
- Extraction, fixation, and immunostaining of tissues followed by microscopy.
- Visualization of molecular interactions in tissues and cell culture, for example through so-called proximity ligation.
- Investigation of signal transduction in tissues by injection of agonists into the circulation, followed by extraction of blood vessel cells (endothelium) and biochemical analysis.
- Execution and participation in structural protein analyses through modeling programs or transmission electron microscopy.
- Genotyping and breeding planning of rodent strains.
- Compilation and statistical analysis of the results, presentation orally and in writing.
- Some managerial functions vis-à-vis others active in the project, both within the own laboratory and external contractors.

Requirements
- Very good theoretical and practical insights and experience of methods for analysis of blood vessel function, especially with regard to blood vessel leakage.
- Excellent skills in statistical analysis methods.
- Very good knowledge in advanced confocal and transmission electron microscopy.
- Excellent social skills, initiative capacity, ability for critical thinking and troubleshooting.
Good verbal and written communication in English.

About the employment
The employment is a temporary position, 12 months. Scope of employment 100 %. Starting date 2025-05-01. Placement: Uppsala

For further information about the position, please contact: Lena Claesson-Welsh, lena.welsh@igp.uu.se

Please submit your application by 28 february 2025, UFV-PA 2025/173.

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