Researcher in Tumor Biology of Exosomes

The Department of Medical Biochemistry and Microbiology (IMBIM) at Uppsala University provides a broad international environment for research and teaching. Research at IMBIM) broadly spans the areas of biochemistry, cell and molecular biology, tumour biology, comparative genetics, functional genomics, immunology, bacteriology, and virology. The research is essentially of fundamental nature, but with relevance and application in health and disease in both animals and humans. More info: Research - Uppsala University (uu.se)

The research programs of the TGFβ signaling and cancer cell differentiation group, headed by Aristidis Moustakas, explores mechanisms of signal transduction and cellular differentiation that lead to the generation of invasive, pro-metastatic cancer cells. Two main themes of the research are: 1) signal transduction by the family of transforming growth factor β (TGFβ) cytokines in the context of human malignancies, 2) mechanisms that link cancer cell differentiation to metastasis, including the epithelial-mesenchymal transition process. More info: Moustakas, Aristidis - Uppsala University (uu.se)

We are now seeking an innovative, energetic and collaborative individual to work as part of our team in a recently initiated study with the aim to characterize the role of extracellular vesicles (EVs, also known as exosomes) downstream of the TGFβ signaling pathway. The project involves high throughput analysis of EV content using quantitative proteomics (mass spectrometry-based). Exhaustive characterization of the content of EVs is underway both at the RNA, protein and lipid level. Deep investigation of molecular mechanisms that generate EVs downstream of the various TGFβ family pathways is a primary goal of the research work. 

Duties:

To lead studies exploring the biogenesis and functions of extracellular vesicles in human tumor models and in association with TGFβ family signal transduction. The work will involve high throughput analyses of macular constituents of the EVs,  based on established methodology in the group and on introduction of new expertise on the EV field by the applicant. The studies will be conducted with close interactions with two other members in the group, the collaborating high throughput facilities and external collaborators. Some teaching may be included.

Required Qualifications:

• PhD exam in cell biology, biochemistry, cancer biology, or other areas relevant to the project, obtained not earlier than 7 years ago (October 2017). A high emphasis will be placed in assessing the suitability of the successful candidate for the team and previous experience and publications in the field of exosomes. 
• Prior experience with quantitative proteomics of cancer cells and tissue and the corresponding secreted EVs is a strong requirement.
• Experience in experimental laboratory-based research is essential.
• Experience of analyzing quantitative proteomics. 
• Excellent oral and written communication skills in English is critical and at minimum beginner level Swedish will be prioritized.

About the employment
The employment is a temporary position until 2025-12-31. Scope of employment 100 %. Starting date 2025-01-15. Placement: Uppsala

For further information about the position please contact: Aristidis Moustakas, aris.moustakas@imbim.uu.se

You are welcome to submit your application no later than 5 November 2024. UFV-PA 2024/3595.