Researcher in Biopharmaceuticals

The Department of Pharmacy at Uppsala University has an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-rate education and extensive collaborations we constitute an important driving force in the development of our academic field. The department has approximately 150 employees and a turnover of approximately 140 million. We are looking for a postdoc in statistics/pharmacometrics.

In this inspiring environment our rich diversity of research groups, several of international prominence, develop and conduct work of great scientific importance. Among our core competences are pharmacokinetics-pharmacodynamics, computational modelling and simulations, in vitro ADME models, advanced in vivo methods, development of biological medicines, as well as patient and societal aspects, from optimizing the use of drugs in individuals to societal pharmaceutical policies. Together, we form a unique cluster of academic competences within pharmaceutical science, playing a key role in shaping the future of pharmacy in both Sweden and globally.

Our scientific focus areas in selection: Pharmacometrics • Pharmacodynamics • Pharmacokinetics • Biologics • Clinical Pharmacy • Drug Delivery • Molecular Pharmaceutics • Pharmaceutics and Nanotechnology • Pharmacoeconomics • Pharmacoepidemiology • Pharmacotherapy • Social Pharmacy

More information www.farmaci.uu.se

Duties
Development of Protein-Based Biological Drugs for Parkinson’s Disease. The aim of the project is to develop a protein-based therapy that is highly specific against the most toxic forms of aggregates in Parkinson’s disease. The project involves the creation, design, and production of antibodies and other binders, as well as analyzing these in vitro to understand how they affect aggregation. Methods used include protein purification with the ÄKTA system, ThT aggregation assays, mass photometry, and toxicity studies in cell assays. We are looking for a motivated person who is good at communication, collaboration and to work independently and who contributes to the nice atmosphere in the group. When selecting the candidate communication and collaboration skills will be important.

Qualifications
We are currently looking for a person with documented experience in the development of biological drugs and who holds a PhD in Parkinson’s disease and biological drugs. The person should be able to work with and have documented experience in the ÄKTA system (affinity purifications, ion exchange columns, and SEC), cell lines and toxicity studies, aggregation assays, Ligand Tracer and other affinity measurements, ELISA, PyMol, and protein design. Some administrative and teaching-related tasks may also be included in the position.

Additional qualifications
It is advantageous if you have experience with in vitro experiments such as flow cytometry.

About the employment
The employment is a temporary position, 12 months. Scope of employment 100%. Starting date 20 November 2024 or as agreed. Placement: Uppsala

For further information about the position, please contact: Lecturer Greta Hultqvist, e-mail greta.hultqvist@farmaci.uu.se .

Please submit your application by 8 November 2024, UFV-PA 2024/3539.

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