Junior Researcher in Tumor Biology with focus on immunology - Hiring in process/Finished, not possible to apply

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Description of the research area

The postdoc position is placed in Senior Professor Lars-Gunnar Larsson’s research group at Department of Pharmaceutical Biosciences, Uppsala University. The research is focused on studies of the function, regulation and targeting of the oncoprotein MYC, which plays and important role in tumor development. This includes studies of the function of MYC in transcription, interactions with cofactors, regulation by the ubiquitin system, targeting MYC with small molecules and the role of MYC in tumorigenesis using mouse models. Lars-Gunnar Larsson’s research group has recently moved from Karolinska Institutet, where the group remains affiliated, see web page: http://ki.se/en/mtc/lars-gunnar-larsson-group

Description of the work

The project addresses the role of MYC in suppression of immune surveillance of tumors.

Immunocompetent mouse models of MYC-induced lung tumors, melanoma and leukemia together with other oncogenes have been established. The task for the successful candidate is to determine if MYC-induced immune suppression in these mouse models can be abrogated by direct or indirect inhibition of MYC and/or factors cooperating with MYC, such as cell cycle kinases. Combinations of anti-MYC and different types of immune therapies are also investigated. These involves studies of interactions between MYC-driven tumor cells and different immune cells and how that affects recruitment, activation and persistence of the immune cells using spatial transcriptomics/proteomics, single cell sequencing and different types of interventions such as by Crispr/Cas9 and immune depletion.

Qualifications

• PhD degree in pharmaceutic science, biomedicine or related area or a foreign exam considered equivalent to PhD degree within these areas. Primarily those that have taken their PhD exam relatively recently and are in the beginning of their research career are taken into consideration.
• Good qualifications regarding work with mouse tumor models, such as transgenic, syngeneic and xenograft models, are required, as well as documented skills in cell and molecular biology and immunology. Proven ability to write scientific articles and a track record of publications in international refereed journals is also required.
• The applicant should have a very good cooperative skills and ability for teamwork, but also ability to work with and to drive projects independently and persistently. Further, the applicant should be curious, creative, take initiatives and build relations. The applicant should have excellent organizational ability, the capacity to work with several concurrent projects in a structured manner, be flexible and able to solve expected and unexpected complex problems. Excellent knowledge in spoken and written English language is a requirement.

The application should contain: 1) A personal letter with description of research interest, 2) CV including date of dissertation, the title of the thesis, previous academic positions, academic title, present position, and academic awards. 3) A complete list of publications, 3) Summary of present and previous work with emphasis on animal models (max two pages), 4) three letters of recommendation. The applicant will be evaluated based on education and previous experience, relevance for the project, publications and track records, motivation, and cooperative ability.

About the employment

The employment is time limited to one year (360 days). The employment is full time (100%). Access to the employment 2024-04-01 or according to agreement. Placement of employment: Uppsala.

For further information about the employment contact Professor Lars-Gunnar Larsson, Lars-Gunnar.Larsson@uu.se

For questions about the employment: Head of administration Marina Rönngren, marina.ronngren@uu.se

Welcome with our application at the latest 20th of March, 2024, UFV-PA 2024/701.