Postdoctoral fellow in Tumor Biology with emphasis on tumor-mediated immunosuppression in mouse models - Hiring in process/Finished, not possible to apply

Postdoctoral fellow in Tumor Biology with emphasis on tumor-mediated immunosuppression in mouse models

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The Department of Pharmaceutical Biosciences is an interdisciplinary environment where 10 research areas work to contribute to better medicines and a healthier world. With laboratories in the heart of Uppsala Biomedical Center and Sweden's only Faculty of Pharmacy, we are a vital engine in the development of education and research in the pharmaceutical sciences. More information about the department and its activities is available at www.farmbio.uu.se.

Description of the research area
The postdoc position is placed in Senior Professor Lars-Gunnar Larsson’s research group at Department of Pharmaceutical Biosciences, Uppsala University. The research is focused on studies of the function, regulation and targeting of the oncoprotein MYC, which plays and important role in tumor development. This includes studies of the function of MYC in transcription, interactions with cofactors, regulation by the ubiquitin system, targeting MYC with small molecules and the role of MYC in tumorigenesis using mouse models. Lars-Gunnar Larsson’s research group has recently moved from Karolinska Institutet, where the group remains affiliated, see web page: http://ki.se/en/mtc/lars-gunnar-larsson-group  

Description of the work
The project addresses the role of MYC in suppression of immune surveillance of tumors. Immunocompetent mouse models of MYC-induced lung tumors, melanoma and leukemia together with other oncogenes have been established. The task for the successful candidate is to determine if MYC-induced immune suppression in these mouse models can be abrogated by direct or indirect inhibition of MYC and/or factors cooperating with MYC, such as cell cycle kinases. Combinations of anti-MYC and different types of immune therapies are also investigated. These involves studies of interactions between MYC-driven tumor cells and different immune cells and how that affects recruitment, activation and persistence of the immune cells using spatial transcriptomics/proteomics, single cell sequencing and different types of interventions such as by Crispr/Cas9 and immune depletion.

Qualifications

• PhD degree in pharmaceutic science, biomedicine or related area or a foreign exam considered equivalent to PhD degree within these areas. The exam should be accomplished at the latest when the employment decision is taken. Primarily those that have taken their exam maximum three years back are taken into consideration. The three years’ time span is calculated from the day of the application deadline. If there are particular reasons, the exam can have been taken earlier than this. With particular reasons are meant leave of absence due to illness, parental leave, union trust assignment, etc.  
• Good qualifications regarding work with mouse tumor models, such as transgenic, syngeneic and xenograft models, are required, as well as documented skills in cell and molecular biology and immunology. Proven ability to write scientific articles and a track record of publications in international refereed journals is also required.
•   The applicant should have a very good cooperative skills and ability for teamwork, but also ability to work with and to drive projects independently and persistently. Further, the applicant should be curious, creative, take initiatives and build relations. The applicant should have excellent organizational ability, the capacity to work with several concurrent projects in a structured manner and solve expected and unexpected complex problems. Excellent knowledge in spoken and written English language is a requirement.  

The application should contain: 1) A personal letter with description of research interest, 2) CV including date of dissertation, the title of the thesis, previous academic positions, academic title, present position, and academic awards. 3) A complete list of publications, 3) Summary of present and previous work with emphasis on animal models (max two pages), 4) three letters of recommendation.

The applicant will be evaluated based on education and previous experience, relevance for the project, publications and track records, motivation, and cooperative ability. Personal suitability is also an important criterion.

About the employment
The employment is time limited to 2 years according to a central collective agreement.  The employment is full time. Access to the employment 2024-02-01 or according to agreement. Placement of employment: Uppsala.

For further information about the employment contact Professor Lars-Gunnar Larsson, e-mail lars-gunnar.larsson@uu.se
For questions about the employment: Administrative Manager Marina Rönngren, e-mail marina.ronngren@.uu.se

Please submit your application by 23d of January 2024, UFV-PA 2023/4834.

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