Research Assistant in neurodegeneration with focus on metabolism - Hiring in process/Finished, not possible to apply

Research Assistant in the research group Molecular Geriatrics

The Research group is part of Molecular Geriatrics unit located within Rudbeck laboratory. It is also tightly tied to the memory clinic located at the university hospital, Akademiska hospital, in Uppsala. The focus of the research unit is diagnostic and therapy of neurodegenerative diseases. Research projects are conducted with other research groups located at the Uppsala University, in Sweden, and internationally; as well as with pharmaceutical companies. 

Oxidative stress and metabolic shift are associated with diverse disorders, including neurodegenerative diseases, such as Alzheimer’s disease (AD). A key component of these alterations are mitochondrial dysfunctions which may contribute, and even drive progression of the disease.  There is growing evidence that mitochondrial dysfunctions are caused by metabolic alterations, which in some cases are irreversible. This project focuses on investigating and modulating metabolic processes linked to mitochondria in human derived cell model systems, with the aim to identify approaches that might delay AD related changes.

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Duties
The direct experimental duties include cell culture work and maintenance (primarily HEK cell, and iPSC work), DNA/RNA isolation and analyses, metabolite/protein assessment in cells and tissue, aid in design and testing of genetically encoded tools for assessment/modulation of metabolic states and processes.

The successful candidate will be responsible to independently design and execute experiments following defined protocols and processes. Additionally, chosen candidate will analyze data, interpret results; and following discussion, optimize and troubleshoot experiments. Along the entire process candidate is required to keep detailed and accurate records of experiments, data, and analysis. Besides direct involvement in experimental work the candidate will be responsible to aid in maintenance of laboratory equipment, and a timely ordering of consumables and supplies.

Requirements
Master's degree, within biomedicine, biological/chemical engineering, life science, pharmacy, or equivalent. We require knowledge and experimental experience within molecular biology, including standard recombinant DNA technology/cloning, proficient in tissue culture techniques, transfections and transductions. Candidate should have experience with working with AAV.

Personal qualities such as good cooperation and communication skills are of the utmost importance. The chosen candidate will possess good time management and have a pro-active attitude. The candidate must be purposeful, structured and able to work effectively both individually and in a team. Great emphasis will be placed on personal suitability. We require good oral and written skills in English.

Additional qualifications
Additionally, it would be advantageous if the applicant has experience of performing studies that include DNA/RNA isolation and analyses with qPCR, digital PCR, protein assessments with Western blot, ELISA, immunolabelling (IHC, IF, ICC), or mass spectrometry. Experimental experience in protein purification and cell isolation is an asset. Research experience in neurological diseases is also a merit.  

Application
Application should be written in English. The CV should contain a list of methodologies the applicant is comfortable with using. Additionally, the application should contain a short personal letter where the applicant describes his/her research interest.

About the employment
The employment is a temporary position, 6 months. Scope of employment 100 %. Starting date 23-03-15 or as agreed. Placement: Uppsala

For further information about the position, please contact: Dr Wojciech Michno wojciech.michno@scilifelab.uu.se

Please submit your application by 17nd of March 2023, UFV-PA 2023/611.

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