PhD student in Medical Science within Neurobiology with focus on Metabolism - Hiring in process/Finished, not possible to apply

The employee will work as part of Molecular Geriatrics, whose activities are carried out at the Rudbeck laboratory and are closely linked to the clinical activities at the Academic Hospital's memory service. The focus group that the employee will be part of does interdisciplinary work using with stem cells and multiomics analyzes as a starting point. Our research complements the larger activities of the Department of Molecular Geriatrics, which is mainly focused on therapy and diagnostics of neurodegenerative diseases. We collaborate with university groups both in Sweden and internationally, as well as with various pharmaceutical companies. Read more about our benefits and what it is like to work at Uppsala University

The role of metabolism in across development and aging, and its disturbances in context of diseases and environmental insults are yet again a popular research topic. Behind this are recent work demonstrating previously unrecognized or often omitted roles metabolism has on neurobiological system homeostasis. Advancements in single cell approaches are fueling the characterization of intricate relationships between spatial and temporal control of metabolites, energy flux, and the role of local microenvironments play in function of individual cells and the broader networks.

In this project the student will work with characterization of metabolic processes in complex human iPSC derived 2D and 3D models (possible work with animals as well), using cutting edge metabolic/lipidomic assessment tool, including those applicable for single cell characterization. The goal is to identify targets for metabolic modulation of senescence, aging and neurological disease progression. A large focus will be given to neurodegenerative disorders including Alzheimer’s disease.

Duties
The doctoral position refers to own full-time studies for a maximum of 4 years. Holders of doctoral employment must primarily devote themselves to their own research training. Other service at the institution, which relates to education and administrative work, may be included within the framework of the employment (max. 20%).

Requirements
Hold a Master’s (second-cycle) degree in in the biomedicine, natural science, pharmacy program or equivalent, great emphasis will be placed on the candidate's competence in thorough cellular and molecular biology.

Have completed at least 240 credits in higher education, with at least 60 credits at Master’s level including an independent project worth at least 15 credits.

Knowledge and experimental experience in molecular biology, including standard recombinant DNA technology/cloning, transfections and transductions. In addition, the applicant must master the following methods: HEK cell culture, iPSC culture, DNA/RNA isolation and analyzes with qPCR, digital PCR.

Read more about the education at PhD level, eligibility requirements and admission regulations 

Additional qualifications
Experimental experience of gene editing with e.g. CRISPR, extractions and HPLC analyses, as well as pathological/histological sample processing are meritorious. Applicants preferably have experience of teaching at individual and group level. Experience working with metabolism in a neuronal context, and/or neural development/aging and related diseases is also desirable.

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines.

Application
The application must be written in English and contain a personal letter that covers the following: a brief description of yourself and the reason why you want to attend a postgraduate course, if you already have any experience in the subject, or techniques you think may be relevant, mention this. These must be accompanied by your CV, copies of diplomas and grades, thesis and a list of any scientific publications. We would like you to provide information about reference persons and/or attach letters of recommendation.

About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Dr Wojciech Michno, Phone: 018-4715060, e-mail: wojciech.michno@scilifelab.uu.se

Please submit your application by 28th of Augusti 2023, UFV-PA 2023/2906.

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