Postdoctoral position in neuro-oncology - Hiring in process/Finished, not possible to apply

The Department of Immunology, Genetics and Pathology at Uppsala University has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: cancer precision medicine, cancer immunotherapy, genomics and neurobiology, molecular tools and functional genomics, neuro-oncology and neurodegeneration and vascular biology. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 500 million, out of which more than half is made up of external funding. The staff amounts to approximately 345 employees, out of which 100 are PhD-students, and there are in total more than 700 affiliated people. Feel free to read more about the department's activities here: www.igp.uu.se

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The position as a post doc is in Lene Uhrbom's research group at the Department of Immunology, Genetics and Pathology. The research projects are centered on functional and molecular studies of primary malignant brain tumors with focus on diffuse gliomas. More information about the research group can be found at: www.igp.uu.se/research/node/leneuhrbom

The selected candidate will conduct research in the field of neuro-oncology. An important part of the work will be to establish new patient-derived cell cultures (2D, 3D, organotypic slice cultures) and perform analyses on these (part of an EU-financed project in collaboration with national and international biotech companies) to identify new candidate drugs. The other part of the work will be to conduct basic research to understand the biology behind the therapy evasive nature of glioblastoma cells and use that knowledge to develop new therapies.

Work description:
- Establish new cell cultures from patients with brain tumors.
- Perform phenotypic, functional and molecular analyses in vitro.
- Analyze response to drug candidates in 2D, 3D and organotypic slice cultures.
- Perform analyses of mouse cancer models.
- Actively take part in compiling data and results for publications and applications.
- Assist as mentor for undergraduate and graduate students.
- Share expertise with and educate members of the group.
- Work in close collaboration with and report to researchers in an EU-financed consortium.

Requirements
PhD degree in cancer biology or a foreign degree equivalent to a PhD degree. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.
- Previous experience of tissue culture work.
- Deep conceptual understanding of cancer biology.
- Theoretical and experimental knowledge of tissue, cell and molecular biology methods and analyses.
- Excellent organization and documentation skills.
- Excellent collaboration and adaptation skills, i.e. to be able to work effectively in a dynamic, multidisciplinary and multicultural environment.
- Excellent communication skills, both oral (discussions, meetings, presentations etc) and in writing (emails, reports, applications, publications etc).

Additional qualifications:
- Extensive knowledge in brain tumor biology
- Experience of: establishment of patient-derived cell cultures, maintaining cell cultures under stem cell conditions, 3D cell cultures, organotypic slice cultures, dose-response analysis and drug testing, bioinformatic analyses.
- LAS certificate and experience of working with mouse cancer models.
- Experience of driving a project from idea to publication in a journal of high international standard.

About the employment
The employment is a temporary position of 2 years according to central collective agreement with the possibility of up to 1 year extension. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Lene Uhrbom, lene.uhrbom@igp.uu.se, 018-471 5063

Please submit your application by 17 March 2023, UFV-PA 2023/457.

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