PhD student in antibiotic resistance - Hiring in process/Finished, not possible to apply

PhD student in antibiotic resistance

The Department of Medical Sciences is a large clinical institution with more than 250 employees and over 900 additional coworkers connected via the Uppsala University Hospital. The Department of Medical Sciences has a broad research profile with strong research groups in a number of different areas. The research carried out at the department is performed in close connection with the clinical activities at the Uppsala University Hospital, which includes both basic studies on the causes of a variety of illnesses and the development and evaluation of improved diagnostics and new treatment methods. More information about the Department of Medical Sciences can be found at www.medsci.uu.se

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Project description
Thomas Tängdén’s research group conducts in vitro studies on antibiotics and resistant bacteria. The purpose of the planned project is to find antibiotic combinations that are effective against multidrug-resistant bacteria and can suppress emergence of resistance. Also, we will investigate how antibiotic dosing can be optimized. In the studies, we use clinical isolates as well as laboratory strains in which we have modified the setup of genes encoding enzymatic resistance and impermeability (porin loss). The effect of antibiotics is investigated by MIC-testing, static and dynamic time-kill experiments and automated time-lapse microscopy with subsequent image analysis. The project also includes handling and analysis of whole-genome sequencing data.

Duties
A PhD position lasts for four years and includes both research (including related tasks), courses and literature studies.

Requirements
Basic degree in Biomedicine or other relevant area and further education in e.g. infection biology, molecular biology or microbiology is required (at least 240 higher education credits, of which at least 60 credits should be at an advanced level), as well as good practical skills in the laboratory and good ability to work independently. It is also an advantage if you have practical experience of microbiological laboratory work with bacteria and antibiotics, such as MIC testing and time-kill experiments. Good computer skills in e.g. MS Excel and MS Word are also required. Good knowledge of both Swedish and English is required. In the recruitment, personal qualities including collaboration and communication skills will be of great importance. You are conscientious, structured and methodical in your work, find it easy to see connections, have good reasoning skills and show good judgement.

Additional qualifications
Experience in handling and analyzing sequence data with CLC Workbench or similar

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines.

About the employment
The employment is a temporary position according to the Higher Education Ordinance chapter 5 § 7. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Thomas Tängdén, +46 (0)708 370323, thomas.tangden@medsci.uu.se.

Please submit your application by September 23, 2022, UFV-PA 2022/3205.

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