Postdoctoral position in computational chemistry and structure-based drug design - Hiring in process/Finished, not possible to apply

The Department of Cell and Molecular Biology is one of the most international, broad and distinguished molecular bioscience departments in Europe. The department comprises six research programs (http://www.icm.uu.se). The position is available in Jens Carlsson’s group in the computational biology and bioinformatics programme. Jens Carlsson’s research focuses on using molecular modeling to study protein-ligand interactions, in particular G protein-coupled receptors (GPCRs) and their interactions with drugs. The GPCR superfamily constitutes the largest group of human membrane proteins and plays key roles in physiological processes. The Carlsson group uses structure-based models to understand receptor function and to design ligands of these pharmaceutically important targets, often in close collaboration with experimental groups. The Carlsson group is an international research team and is also part of the Science for Life Laboratory (http://www.scilifelab.se/). Visit the group website for more information (www.carlssonlab.org).

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Duties
The project involves studies of how neurotransmitters bind to GPCRs using molecular dynamics simulations. Central aims of the project are to understand the molecular mechanism of receptor activation and to design new molecules that activate GPCRs using structure-based virtual screening. The project focuses on the adenosine and dopamine receptors and will be carried out in close collaboration with experimental research groups to evaluate modeling predictions.

Requirements
PhD degree in computational chemistry or a foreign degree equivalent to a PhD degree in the same area. The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc. Strong abilities in computational chemistry with experience in molecular dynamics simulations of proteins are required. Excellent written and oral knowledge of English is required as the work takes place in an international environment.

We attach great importance to personal qualities, in particular good collaborative abilities, motivation, and independence.

Additional qualifications
Experience in modelling of GPCRs, molecular docking or scientific programming is preferred, but not required. 

About the employment
The employment is a temporary position of two years according to central collective agreement. Scope of employment 100 %. Starting date as soon as possible or as agreed. Placement: Uppsala

For further information about the position, please contact: Jens Carlsson, jens.carlsson@icm.uu.se, Tel: +46 (0)72 227 7976.

Please submit your application by March 1 2022, UFV-PA 2022/295.

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