Researcher with a focus on morphological cell profiling - Hiring in process/Finished, not possible to apply

The Department of Pharmaceutical Biosciences has 125 employees as well as a number of guest researchers and fellows. The department has fifteen research groups / research areas with a joint administration and we conduct research and teaching in pharmaceutical cell biology and biotechnology, biochemistry, immunology,  biological drugs / biotechnology, pharmacology, pharmaceutical and drug addiction , pharmacognosy, galenic pharmacy, bioinformatics, imaging mass spectrometry, molecular neuropharmacology,  as well as toxicology and drug safety. More information about the department and its activities can be found at www.farmbio.uu.se

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Description
Uppsala University is establishing a new node as part of the Chemical Biology Consortium Sweden (www.cbcs.se), a national infrastructure for chemical biology. CBCS operates in a highly collaborative fashion in projects with academic and industrial users, offering a platform for the identification of chemical tools (bioactive small-molecules) for all fields of life sciences (molecular-, cell-, structural biology and microbiology, pharmacology; natural product and environmental research, etc.). The UU node will offer services focused on cell profiling and screening primarily using the Cell Painting assay.

We are looking for an experienced Researcher to join our team and establish Cell Painting (high-content imaging of cells using multiplexed fluorescent dyes) as a methodology that can be offered as a service to Swedish researchers. The position is placed at the Department of Pharmaceutical Biosciences located at the Biomedical Center (BMC), Uppsala University, where you will work closely with a team of biologists, data scientists, and engineers in close collaboration to the Pharmaceutical Bioinformatics research group (https://farmbio.uu.se/research/pharmaceutical-bioinformatics/), with occasional on-site collaborations with collaborators at Karolinska Institutet in Solna.

Duties
The activities will include:

• Standardization of Cell Painting in diverse cell models including cancer cell lines and primary cells
• Development of cell-line specific image analysis pipelines
• Generation of reference datasets for selected drug libraries
• Interaction with the rest of the team to establish the necessary lab infrastructure, protocols, and data analysis required for a service facility

You will operate in an international team in a vibrant research environment, in close collaboration with researchers from diverse backgrounds.

Requirements
Solid experience in cell-based experimentation and molecular biology techniques such as immunofluorescence staining, cell-based assay development and lab protocol optimization. Experience of laboratory automation including robotized liquid handling as well as the use of automated microscopy and image analysis is a requirement. Experience from profiling and screening of chemicals / drugs and the Cell Profiler software is meriting. General computer proficiency and excellent communication skills in written and spoken English are essential, as well as documentation skills and experience with electronic lab notebooks. Special emphasis will be placed on strong interpersonal skills such as independence, flexibility, perseverance and initiative, as well as social skills such as collaborative ability.

About the employment
The employment is a temporary position, 12 months. Scope of employment 100%. Starting date immediately or as agreed. Placement: Uppsala.

For further information about the position, please contact: professor Ola Spjuth, e-mail Ola.Spjuth@farmbio.uu.se

Please submit your application by 19 January 2022, UFV-PA 2021/5063.

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