Researcher in Structural Biology - Hiring in process/Finished, not possible to apply

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.

The Cell and Molecular Biology department at Uppsala University has a strong and international research and teaching environment and is organized in six major research programs; Computational Biology and Bioinformatics, Microbiology and Immunology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology, and Structural Biology. In total the department has over 200 scientists, including 60 PhD students.

The position is with the research group of Anna Sundborger-Lunna in the ICM Program in Structural Biology, https://www.icm.uu.se/structural-biology/. The Sundborger-Lunna lab uses a combination of molecular biology, biochemical and structural biology techniques, including cryo-electron microscopy, to study how membrane-remodeling proteins regulate critical cell death processes. Our goal is to understand the interplay between proteins and membrane lipids in the control of cell fate and neurodegeneration. Uppsala University recently installed a 200kV Glacios cryo-electron microscope with a Falcon III direct electron detector and another facility housing a 300kV Titan Krios equipped with a K3 detector with an energy filter is located nearby, at the SciLifeLab campus in Solna, less than 60 min from Uppsala: https://www.scilifelab.se/units/cryo-em/.

Read more about our benefits and what it is like to work at Uppsala University

Duties
The candidate will use cryo-EM to characterize protein complex with the end goal of solving the 3D structure of protein complexes and protein fibrillar structures. The candidate will also perform associated biochemical experiments and contribute to publication of results in scientific journals.

The candidate is expected to be able to take charge of this NINDS-funded project, and be responsible for establishing and maintaining a workflow for sample screening at the local cryo-EM facility at ICM and data collection at the SciLifeLab in Solna (Titan Krios och Talos Arctica), including support for other lab members.

Requirements
The applicant must have a PhD in biochemistry, structural biology or an equivalent area that the employer assesses as equivalent. The applicant should have experience with cryo-EM sample preparation, microscopy operations, image processing and model building. Experience of Linux-based computational clusters and using Relion, cryoSPARC or similar software packages is also required.

Great emphasis will be placed on personal skills and characteristics, such as great interpersonal skills. The applicant must also have excellent communication skills in English, which is a prerequisite for the service due to the international environment, and an ability to work independently as well as in groups.

Additional qualifications

• Previous work with amyloids
• Previous work with chaperones
• Experience of cryo-EM analysis of amyloid proteins and fibrils (helical image processing)
• Experience of protein expression and purification

The application
Your application must include a personal letter where you describe yourself, your research interest, experiences and why you are interested in and suitable for the position (max 2 pages). CV containing your education, other qualifications and publication list. Copy of your PhD diploma and of your thesis (can be provided as a link). Contact information (E-mail and telephone) of two reference persons.

About the employment
The employment is a temporary position, 12 months. Scope of employment 100 %. Starting date 2022-03-01 or as agreed. Placement: Uppsala

For further information about the position, please contact: Anna Sundborger-Lunna, anna-sundborger-lunna@icm.uu.se, + 46 (0) 76 047 28 07.

Please submit your application by January 3rd 2022, UFV-PA 2021/5035.

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