Researcher in blood-brain barrier pharmacokinetics of biologics - Hiring in process/Finished, not possible to apply

The Department of Pharmacy at Uppsala University has an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research, first-rate education and extensive collaborations we constitute an important driving force. In this inspiring environment our rich diversity of research groups, several of international prominence, develop and conduct work of great scientific importance. Among our core competences are in vitro ADME models, advanced in vivo methods, computational modelling and simulations, as well as patient and societal aspects, from optimizing the use of drugs in individuals to pharmaceutical policies. Together, we form a unique cluster of academic competences within pharmaceutical science, playing a key role in shaping the future of pharmacy in both Sweden and globally.

Our scientific focus areas in selection:

• Clinical Pharmacy
• Drug Delivery
• Molecular Pharmaceutics
• Pharmaceutics and Nanotechnology
• Pharmacoeconomics
• Pharmacoepidemiology
• Pharmacokinetics
• Pharmacometrics
• Pharmacotherapy
• Social Pharmacy

More information at Department of Pharmacy

Read more about our benefits and what it is like to work at Uppsala University

Project description
The researcher will be working in the research group of Translational Pharmacokinetics and Pharmacodynamics (tPKPD). The group takes a multidisciplinary approach to improve the understanding of fundamental and functional aspects of PKPD in health and disease, with special focus on drug delivery to the brain. We are interested in brain drug delivery in relation to transport processes of both small and large molecules across the CNS barriers including the blood-brain barrier (BBB). This is pursued in a translational setting.

The researcher will focus on in vivo characterization and validation of novel BBB targets and their potential for brain delivery of biotherapeutics using pharmacokinetic methods. The project is an important part of the EU IMI2-RIA funded project IM2PACT - Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics Into The Brain (IM2PACT). In short, IM2PACT is a consortium of 27 international partners from academia, industry, and small and medium enterprises that aims to tackle the unmet challenge of discovery and characterization of blood-brain barrier targets and transport mechanisms for brain delivery of therapeutics, to treat neurodegenerative and metabolic diseases. The project gives access to a highly international work environment and network of researchers both from academia and industry.

Duties
The successful candidate should have a PhD in pharmacokinetics, pharmaceutical, biomedical or medical sciences, or related areas. To qualify for an employment you must have a PhD degree not older than 7 years.

Special weight is put on in vivo skills in preclinical research including a FELASA C certificate, on experience with in vivo pharmacokinetic studies, and data analysis. 

You must be able to work independently and take initiatives, but also be part of the team and collaborate with our partners in the IM2PACT consortium. Emphasis is put on personal suitability. The applicant must also have good communication skills in English.

Additional qualifications
Knowledge on structure and function of CNS barriers including blood-brain barrier, blood-CSF barrier in health and disease, as well as a good understanding of transport mechanisms across the brain barriers is valuable, as is experience with studying biotherapeutics (e.g. antibodies or peptides).

How to apply
The application should contain the following:

A personal letter in which the applicant describes her- or himself, motivates why he/she has applied for the position, states relevant qualifications and indicates research interests and plans for the future, A CV including a list of publications, contact details of at least two references, authorized copies of relevant certificates, degrees and grades.

We only accept applications with the requirements outlined above.

About the employment
The employment is a temporary position, 12 months with possible prolongation. Scope of employment 100%. Starting date 1 February or as agreed. Placement: Uppsala.

For further information about the position, please contact: Ass. Professor Irena Loryan, e-mail mail to: irena.loryan@farmaci.uu.se, +4618-471 4995 or HR-generalist Pernilla Larsson, pernilla.larsson@farmaci.uu.se, +4618-471 5394.

Please submit your application by 14 January 2022, UFV-PA 2021/4852.

Are you considering moving to Sweden to work at Uppsala University? Find out more about what it´s like to work and live in Sweden.