Researcher position in molecular hematology with a focus on AML - Hiring in process/Finished, not possible to apply

The Department of Immunology, Genetics and Pathology at Uppsala University (www.igp.uu.se) has a broad research profile with strong research groups focused on cancer, autoimmune and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: medical and clinical genetics, clinical immunology, pathology, neuro-oncology, vascular biology, radiation science and molecular tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology, and Hospital Physics at Akademiska sjukhuset, Uppsala. The department has teaching assignments in several education programmes, including Master Programmes, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The department has a yearly turnover of around SEK 450 million, out of which more than half is made up of external funding. The staff amounts to approximately 345 employees, out of which 100 are PhD-students, and there are in total more than 700 affiliated people.

The position as Researcher is in Dr. Linda Holmfeldt’s group at the Department of Immunology, Genetics and Pathology. The research group focuses on studying acute leukemia using a combination of genomics, cell- and molecular biology techniques, and in vivo models. Further information about the research group can be found at http://www.igp.uu.se/research/experimental-clinical-oncology/linda-holmfeldt/?languageId=1

Work description: The aim with the project is to functionally characterize alterations we have identified in the gene UBTF in pediatric acute myeloid leukemia. The work includes detailed molecular biological, omics-related analyses and cellular in vitro analyses, as well as in vivo studies to investigate the role of these specific mutations within leukemogenesis. Further, pharmacological evaluations will be performed in the above described systems.

Qualifications required:

- Doctoral Degree in a for the project relevant subject.
- Extensive experience in standard molecular biology techniques.
- Extensive experience of cell culture work; preferably leukemia cell lines.
- Experience of bioinformatics related to next-generation sequencing data analysis and R programming.
- Excellent skills within planning and executing experiments.
- Excellent skills within written and oral communication in English.
- Good teamwork skills.

Qualifications desired:

- Experience of CRISPR-Cas9 related work.
- Experience of dd-PCR related work.
- Experience of lentiviral transduction.
- Experience of flow cytometry.
- Experience of mass spectrometry based proteomics.
- Experience of microscopy, including fluorescence microscopy.
- Holder of FELASA-C certificate.

The application must include a CV, copies of diplomas and certificates, and a personal letter including a short description of your research interests. Also include contact details of two references. Applications will be assessed according to the following criteria: Appropriate education and previous work and/or research in a related field. In addition, an emphasis will be placed on personal aptitude.

Salary: According to individual qualifications.

Start date: As soon as possible or according to agreement.

Form of employment: General temporary employment of one year with the possibility of extension for one more year.

Extent of employment: 100%.

For more information contact: Dr Linda Holmfeldt, email: linda.holmfeldt@igp.uu.se.

You are welcome to apply no later than 25 March 2021, UFV-PA 2021/854.
 

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