Researcher position in Molecular Biophysics - Hiring in process/Finished, not possible to apply

This position is located at the Department of Cell and Molecular Biology starting as soon as possible. The Cell and Molecular Biology department at Uppsala University has a strong and international research and teaching environment and is organized in six major research programs; Computational Biology and Bioinformatics, Microbiology, Molecular Biophysics, Molecular Evolution, Molecular Systems Biology, Structure and Molecular Biology. In total the department has over 200 scientists,
including 70 PhD students.

The current position is located within the research group of Filipe Maia within the Molecular Biophysics. More information can be found at https://biox.io/ and https://lmb.icm.uu.se.

Project description: Detecting the atomic structure of biomolecules is the basis for understanding biological function at the molecular level. This knowledge has led to enormous scientific advances, important drugs, and disruptive technologies. Structural methods exist, but many biomolecules have escaped structure determination; structural changes due to interactions cannot be easily characterized, and enzymatic mechanisms are hard to detect due to an insufficient time-resolution. The project will develop fluctuation correlation X-ray scattering (FXS) with powerful X-ray freeelectron
lasers (XFEL), capable of producing extremely intense and ultra-short X-ray pulses radiation, which promises to determine the structure of biomolecules in biologically native conditions with lighttriggered pump/probe experiments. The method is a natural extension of traditional small-angle X-ray scattering (SAXS). It has been demonstrated in 1977 by Kam for macroscopic objects based on scattering by visible light. Recent reports indicate that it is in principle possible to determine the structure of proteins in solution with FXS. If successful, this project will establish FXS as a new method for structure determination of biomolecules in native, ‘biological‘, conditions.

Duties: The applicant is expected to drive multiple ambitious projects within the area. The position involves carrying out FXS experiments on biological samples at leading XFELs along with all the associated preparation and analysis of the resulting data. The project aims to build up a new experimental setup, the position therefore also involves work on designing and developing this new setup. Oral presentation and writing/editing of scientific papers and grant applications are part of the position.

Requirements: To qualify for this position you must have a PhD degree or a foreign
degree equivalent to a PhD degree in physics, biophysics or in a area similar to these. We are looking for a highly-motivated candidate who is able to work independently and has a strong interest in coherent X-ray imaging and method development. You are expected to take your own initiatives as well as being able to collaborate with other colleagues both within and outside the research group. The position is in an international context so good oral and written communication skills in English are essential. Finally, significant weight will be given to personal suitability such as; analytical and organizational skills, personal maturity, ability to work with others, take initiatives, and to show good judgement.

Additional qualifications:

• Documented experience with fluctuation X-ray scattering (FXS) is an advantage.
• Documented experience with gas dynamic virtual nozzles (GDVNs) is an advantage.
• Documented experience with X-ray experiments, specially at XFELs, is an advantage.

Application: Please submit your application including:

1. CV
2. a letter describing your research interests, skills and motivation to apply for the position (max 2 pages)
3. diplomas
4. list of publications
5. up to three reference letters

Salary: Individual salary.

Starting date: As soon as possible or as otherwise agreed.

Type of employment: Temporary position of two years.

Scope of employment: 100 %.

For further information about the position please contact: Filipe Maia filipe@xray.bmc.uu.se

Please submit your application by November 5th 2020, UFV-PA 2020/3748.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.