PhD position in multiplexed sensor for detection and analysis of exosomes for cancer diagnosis - Hiring in process/Finished, not possible to apply

PhD posistion are in the subject Electronics with specialization in biological and medical sensor technology, at the Angstrom Laboratory, Department of Electrical Engineering, Division of Solid State Electronics.

Project description: Exosomes and other types of nano-scale extracellular vesicles (EVs), secreted by all cell types, have been found to take part in a highly sophisticated intercellular communication, thereby offering a unique opportunity for diagnostic and therapeutic intervention in various pathological conditions including cancer. Released in various body fluids, these vesicles constitute an important form of biomarkers for “liquid biopsy concept” allowing for non-invasive diagnostics and treatment monitoring.

In this project, the aim is to develop a silicon nanochip-based method to isolate exosomes and determine their parent cell of origin by multiple analyses of protein expression and RNA/micro-RNA content. This will allow a quantitative detection and monitoring of tumors at a high sensitivity, resulting in a method for early detection of cancer and also enabling therapy monitoring with biomarkers of relevance for therapy decision. This multidisciplinary project involves strong collaboration among the partners from KTH, Scilifelaboratory, Karolinska Institute and RISE Acreo and combines expertise and state-of-the-art methodologies from genomics, proteomics, nanotechnology and clinical oncology.

Duties:
The PhD project will focus on two areas:

• Design, fabrication and optimization of Si sensor chip
• Surface protein profiling of extracellular vesicles.

The main duties are to devote the research studies, which includes participating in research projects and third cycle courses. The work duties also include teaching and other departmental duties (no more than 20%).

Requirements: The candidate should have a master of science degree (or equivalent) in physics, engineering physics, material science, or electronics. Strong collaboration spirit and good communication skills in oral and written English are required.

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines http://regler.uu.se/?languageId=1.

Application: Should include a brief description of research interest and past experience, a CV, copies of exams, degrees and grades, university transcripts for all degrees if applicable, a copy of your Master thesis (or a draft thereof) and other relevant documents. The candidates are encouraged to provide letter(s) of recommendation and contact information of reference persons.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: According to local agreement for PhD students.

Starting date: As otherwise agreed.

Type of employment: Temporary position according to the Higher Education Ordinance chapter 5 § 7.

Scope of employment: 100 %

For further information about the position please contact: Dr. Apurba Dev, e-mail: apurba.dev@angstrom.uu.se, phone: +46 734606754. 

Please submit your application by April 15 2020, UFV-PA 2020/673.

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