Scientist ADME Bioanalys - Hiring in process/Finished, not possible to apply

The Science for Life Laboratory (SciLifeLab) is collaboration between four universities in Stockholm and Uppsala: Stockholm University, Karolinska Institutet, the Royal Institute of Technology, and Uppsala University. The SciLifeLab is a national center for bioscience with a focus on health and environmental research. The center combines advanced technical know-how and state-of-the-art equipment with a broad knowledge in translational medicine and molecular biosciences. As part of this effort, the national platform for academic drug discovery and development was established within SciLifeLab – the SciLifeLab Drug Discovery & Development Platform (SciLifeLab DDD).

ADME of Therapeutics (ADMEoT) facility (Uppsala University Drug Optimization and Pharmaceutical Profiling-UDOPP) is organized at the Department of Pharmacy, Uppsala University and is part of the SciLifeLab DDD. The primary aim of ADMEoT (UDOPP) is to perform in vitro ADME (Absorption, Distribution, Metabolism and Excretion) studies and pharmaceutical profiling of hit collections and compound series during the lead generation/ optimization stage of the drug discovery process. The facility also provides preclinical characterization and performs bioanalytical services.

UDOPP (ADMEoT) is also affiliated to the Innovative Medicine Initiative (IMI), New Drugs for Bad Bugs (ND4BB) program, European Gram Negative Antibacterial Engine (ENABLE) consortium and to the IMI, ConcEPTION program. For more information, please visit the UDOPP homepage: https://farmaci.uu.se/research/drugdelivery/udoppeng/

The Department of Pharmacy at Uppsala University is now recruiting a bioanalysis/ADME scientist to contribute to academic drug discovery projects within the SciLifeLab DDD. The position will be placed at SciLifeLab DDD, ADME of Therapeutics (UDOPP) facility at the Department of Pharmacy, Uppsala University.

Duties: Purpose of the position is to provide scientific expertise and contribute to academic drug discovery (DD) projects ongoing at the SciLifeLab DDD. The major objective is to run bioanalysis of in vitro ADME samples and of in vivo (plasma, homogenate target tissues etc) samples for small molecules and biopharmaceutical drug candidates. The candidate’s responsibilities would include data analysis, reporting and gathering data for project meetings. The candidate’s role will also be to complement work of the ADME team with analytical expertise. Within the role there will also be tasks of performing routine in vitro ADME experiments.

The selected candidate will be responsible for:

• Sample preparation and quantitative analysis of in vitro and in vivo samples of small molecule and biopharmaceuticals using LC-MS/MS technique.
• Quantitative bioanalysis of antibodies in biological matrices using immunoassays, i.e. DELFIA, ELISA.
• Develop and execute MS-based assays for proteomic and metabolomic samples, processing and reporting of the results.
• Ability to develop, evaluate and implement new technologies with focus on expanding the existing LC-IM-HRMS (liquid chromatography-ion mobility -high-resolution mass spectrometry) capacity.
• Share analytical expertise with other members of the ADMEoT facility and SciLifeLab DDD.
• Day-to-day regular lab work including in vitro ADME within diverse drug discovery projects.
• Reporting of the ADME results to respective project forums in a timely and orderly manner.

Requirements: A PhD in bioscience with a specific focus on bioanalysis of in vitro and in vivo samples using LC-MS/MS technique. In-depth knowledge and several years of practical experience working with liquid chromatography coupled to mass spectrometry such as e.g. Q-Exactive HF Orbitrap (Thermo Scientific) equipped with nano/micro LC, IM-QToF (Waters) and common triple quadrupole system are a must. 

Additional, hands-on experience with analytical software X-calibur, MassLynx, Proteome Discoverer, Compound Discoverer and Trace Finder, analytical sample preparation and reporting of the analysis of test compounds in biological matrices (plasma and tissue homogenates) are crucial.

The successful candidate is expected to have high degree of integrity, motivation, flexibility and capability of working in a structured and efficient way. Excellent interpersonal and cooperation skills as well as ability to work in interdisciplinary teams are essential. Outstanding collaboration skills and dedication to satisfy remote collaborating partner’s needs are expected.

Additional qualifications: Experience with metabolomic and biomarker analysis is an advantage. Detailed understanding of common proteomic assays and techniques, from basic proteolytic digestions to more complex quantitative and qualitative proteomic analysis is desired.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: Individual salary.

Starting date: 01-01-2020 or as otherwise agreed.

Type of employment: Temporary position ending 31-12-2020.

Scope of employment: 100%

For further information about the position please contact: Pawel Baranczewski, e-mail pawel.baranczewski@farmaci.uu.se, phone +46 (0)18 4714067.

Please submit your application by 8 November 2019, UFV-PA 2019/3523.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.