PhD position in Molecular Bioscience - Hiring in process/Finished, not possible to apply

The Department of Cell and Molecular Biology is one of the most international, broad and distinguished biomolecular departments in Europe, comprising six research programs with about 130 employees. Please read more at www.icm.uu.se

Duties/Project description
It is known that in E. coli, initiation of chromosome replication starts bidirectionally from a single origin of replication (oriC) and is mediated by binding of several copies of the replication initiation protein DnaA together with the coordinating protein DiaA. The coordination of initiation with division cycle is generally described as being “complex”, and although a number of theoretical models have been suggested during the last 30 years, none of these are plausible in the light of the sensitivity seen in recent experiments.

To get to the mechanism, we will use large-scale screening to identify potential regulatory proteins and depending on the result we will be considering different quantitative models. The DuMPLING screen (Lawson et al. Mol. Syst. Biol. 2017) has been developed in the lab during the last couple of years and will be used in the initial phase. Potential candidates will then be investigated further using conventional KO/KD strategies. The results will be used to generate hypothesizes and new quantitative models for the mechanisms coordinating the replication and division cycle in E. coli.

Requirements
You have a passion for science and high ambitions to perform top quality research. You hold a master degree in a relevant subject area; you have good knowledge of single molecule imaging of fluorescent molecules in living cells and you are proficient in molecular cloning techniques, protein purification and florescence labelling. You have good programming skills. Personal qualities, ability to work independently and at the same time be able to interact with other researchers are very important. Excellent communication skills in written and spoken English are prerequisites.

Meriting
Experience with microfluidic techniques for studies of bacterial cells. Good knowledge of the bacterial cell cycle and regulation of replication initiation.

Application
Your application should include a brief description of research interests and relevant experience, a CV, copies of diplomas and certificates, thesis as well as other relevant documents that the applicant wishes to refer to.

Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines http://regler.uu.se/?languageId=1.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: According to local agreement for PhD students.
 
Starting date: As soon as possible or as otherwise agreed.

Type of employment: Temporary position according to the Higher Education Ordinance chapter 5 § 7.

Scope of employment: 100 %

For further information about the position please contact: Irmeli Barkefors, +46 18 471 6681, irmeli.barkefors@icm.uu.se

Please submit your application by September 19th 2019, UFV-PA 2019/3018.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.