ADME Analysis Scientist - Hiring in process/Finished, not possible to apply

ADME of Therapeutics (ADMEoT) facility (Uppsala University Drug Optimization and Pharmaceutical Profiling-UDOPP) is organized at the Department of Pharmacy, Uppsala University. The primary aim of ADMEoT (UDOPP) is to perform in vitro ADME (Absorption, Distribution, Metabolism and Excretion) studies and pharmaceutical profiling of hit collections and compound series during lead generation/optimization stage of the drug discovery process. The facility also provides preclinical characterization and performs bioanalytical services.

The Science for Life Laboratory (SciLifeLab) is collaboration between four universities in Stockholm and Uppsala: Stockholm University, the Karolinska Institute, the Royal Institute of Technology, and Uppsala University. The SciLifeLab is a national center for large-scale biosciences with a focus on health and environmental research. The center combines advanced technical know-how and state-of-the-art equipment with a broad knowledge in translational medicine and molecular biosciences. As part of this effort, the national platform for academic drug discovery and development was established within SciLifeLab – the SciLifeLab Drug Discovery & Development Platform (SciLifeLab DDD). UDOPP (ADMEoT) is currently affiliated to the SciLifeLab DDD and to the Innovative Medicine Initiative (IMI), New Drugs for Bad Bugs (ND4BB) program, European Gram Negative Antibacterial Engine (ENABLE) consortium. For more information, please visit the UDOPP homepage at: http://www.farmfak.uu.se/farm/udopp/index.html

The Department of Pharmacy at Uppsala University, is recruiting an ADME/Analysis scientist to contribute drug discovery projects within the SciLifeLab DDD. The position will be placed at SciLifeLab DDD, ADME of Therapeutics (UDOPP) facility at the Department of Pharmacy, Uppsala University.

Purpose of the position is to provide scientific expertise and contribute to the academic drug discovery (DD) projects ongoing at the SciLifeLab DDD. The major objective is to run analysis of the in vitro ADME samples and bioanalysis of the in vivo (PK) samples. The candidate’s role will be to perform in vitro ADME and PK experiments specific to the DD projects. The candidate responsibilities would also include data analysis, reporting and gathering data for project meetings. The candidate’s role would be also to complement work of the ADME team with analytical expertise.

Duties: The selected candidate will be responsible for:

• Sample preparation and quantitative analysis of in vitro and in vivo samples using LC-MS/MS technique,
• Quantitative bioanalysis of antibodies in biological matrices using immunoassays, i.e. DELFIA;
• Develop and execute mass spectrometry-based assays for proteomics and metabolomics samples, processing and reporting of the results,
• Day-to-day regular lab work including: in vitro ADME within diverse drug discovery projects,
• Reporting of the ADME results to respective database(s) in a timely and orderly manner,
• Ability to develop, evaluate and implement new technologies with focus on expanding the existing LC-HRMS (high-resolution mass spectrometry) capacity,
• Share analytical expertise with other members of the ADMEoT facility and SLL DDD.

Requirements: A PhD in bioscience with a specific focus on analysis of in vitro and in vivo samples using LC-MS/MS techniques. In-depth knowledge and several years of hands on experience working with high-resolution mass spectrometry such as Q-Exactive HF Orbitrap (Thermo Scientific) equipped with nano LC and on triple quadrupole Waters TQ-S system connected to UPLC system are a must. 

Additional, hands-on experience with analytical software X-calibur, MassLynx, analytical sample preparation and reporting of the analysis of test compounds in biological matrices (plasma and tissue homogenates) are crucial.

The successful candidate is expected to have high degree of integrity, motivation, flexibility and capability of working in a structured and efficient way. Excellent interpersonal and cooperation skills as well as ability to work in interdisciplinary teams are essential. Outstanding collaboration skills and dedication to satisfy remote collaborating partner’s needs are expected.

Additional qualifications: Detailed understanding of common proteomic assays and techniques, from basic proteolytic digestions to more complex quantitative and qualitative proteomic analysis is desired. 

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Salary: Individually negotiated salary.

Starting date: 01-10-2018 or as otherwise agreed.

Type of position: Permanent full-time position, probationary period may be applied alternatively Temporary part-time position (100%) ending 28-02-2018.

For further information about the position please contact
(Pawel Baranczewski +46 (0) 4714067 Pawel.baranczewski@farmaci.uu.se)

Please submit your application by 23 Augusti 2018, UFV-PA 2018/2727.

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact International Faculty and Staff Services at ifss@uadm.uu.se.