Post-doctoral researcher in Analytical Chemistry - Hiring in process/Finished, not possible to apply

The Department of Chemistry – BMC is located at the Uppsala Biomedical Centre campus. It belongs to the Faculty of Science and Technology and conducts research in biochemistry, organic chemistry, analytical chemistry, and physical chemistry. The research is focused on catalysis, molecular recognition, structure and dynamics of complex molecular systems, and relationships between the presence of biomolecules and synthetic chemical compounds with various disease states. There is also strong research in method and technology development, including the design and synthesis of small organic molecules and biological macromolecules. Development of new biochemical and analytical methods are the basis for advanced studies of biological systems and their regulation, and how diseases can be diagnosed and treated. The department benefits from close contacts with other disciplines nearby and interacts with biomedicine, pharmacy, physics and materials science. Scientists with expertise in biophysical methods of interaction analysis are responsible for a facility belonging to SciLifeLab, part of a national infrastructure for research in life science. The creative and research-intense environment contributes to a broad knowledge-base as well as cutting-edge expertise. In addition, Uppsala University has a highly developed innovation office that gives support for commercialization and external collaboration. Click here to read more about us.

Uppsala University offers one of the country’s best educations in chemistry, with strong links to world- leading research. A wide range of courses, excellent research connections, and extensive lab work characterizes the teaching. Together with our colleagues at the Department of Chemistry – Ångström, we are responsible for the Bachelor and Master programs in Chemistry, and the Master of Science in Chemical Engineering, together with the Faculty of Pharmacy. We provide courses and parts of courses to other education programs, both within and outside the faculty. Click here to read more about our education.

We are looking for a post-doctoral researcher in Analytical Chemistry, temporary position for two years.

We will study how frequent and to which extent cellular heterogeneity exists, and other aspects of cell-to-cell signaling, such as their release of neuropeptides and peptide hormones. This will be done through method development where peptide release can be studied online from living cells with mass spectrometry and through single-cell profiling of chemical content.  We will also develop methods for studies of molecular interactions between neuropeptides and their cognate receptors. The project is funded by the Swedish Foundation for Strategic Research and will over time provide information that is key for future drug design of biological therapeutics.

Duties: Advanced research with emphasis on biological mass spectrometry, in particular through single-cell studies of neuropeptides and characterization of ligand–receptor interactions. The project will consider peptidergic cells from several model systems to study cellular heterogeneity with quantitative and qualitative analysis. An important part of the project considers work with cellular overexpression of membrane proteins such as G-protein coupled receptors and ion channels, to improve our understanding of their structure–function relationships. The project will rely upon MALDI- and high-resolution ESI MS, liquid chromatography and hydrogen–deuterium exchange.

Qualifications: To be eligible to apply you must have a Ph.D. in chemistry, physics or medicine or an exam, which is judged comparable to a Swedish Ph.D. that was completed within three years of the application deadline. If you received your PhD earlier but special circumstances, prolonged periods of illness, parental leave, military service, union duties and others of similar character, exist you are also eligible to apply.

Excellent expertise in method development for mass spectrometry demonstrated by publications is a requirement for this position. In particular, experience of high-resolution MS, such as Orbitraps are desirable. Experience of cell culture techniques, protein expression, computer programming, liquid chromatography, and previous publications in peer-reviewed journals are also desirable.

We place great emphasis on your personal qualifications. You need to have a strong motivation for the research project and to be able to contribute with creative ideas. This project requires that you are able to work independently, but that you also have excellent collaborative skills, as the project will occasionally require that you are able to collaborate with scientists from other research groups and/or universities. You also need good language skills in English in order to be able to interact, write and publish internationally.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and attracts qualified candidates who can contribute to the University’s excellence and diversity. We welcome applications from all sections of the community and from people of all backgrounds.

Pay: Individual salary

Starting: Will be agreed.

Type of employment: Temporary position, two years

Working hours: 100 %

For further information about the position please contact Dr. Erik Jansson, erik.jansson@kemi.uu.se

You are welcome to submit your application no later than 04-03-2018

Are you considering moving to Sweden to work at Uppsala University? If so, you will find much information about working and living in Sweden at www.uu.se/joinus. You are also welcome to contact the International Faculty and Staff Services at ifss@uadm.uu.se.